| MLO Description | |
|---|---|
| MLO | Stress granule |
| Synonym | Stress granules, SGs |
| Description | Stress granules are large cytoplasmic foci that are nucleated by the aggregation of untranslated messenger ribonucleoproteins (mRNPs), which accumulate as a result of stress-induced translation arrest. These transient, non-membrane-bound organelles are hubs that orchestrate stress responses and cell fate. Stress granule formation can interfere with viral replication because all viruses require the host translation machinery to synthesize viral proteins[1]. Their assembly is triggered by a variety of environmental stresses including heat shock, oxidative stress, hyperosmolarity, viral infection, and UV irradiation, but not X-irradiation or DNA-DNA-damaging agents. Their mRNA composition is selective—they contain transcripts encoding housekeeping genes but exclude those encoding stress-induced genes such as HSP70. Stress granules are found in both cultured cell lines and intact tissues[2]. |
| Reference | 28669985,19467203 |
Chao Hou, Haotai Xie, Yang Fu, Yao Ma, Tingting Li. MloDisDB: A manually curated DataBase of the relations between MembraneLess Organelles and DISeases